Abstract #0407

Hyperpolarised 13C MR Spectroscopy Demonstrates Impaired PDH flux In the Diabetic Human Heart, Correlating with Impaired Energetics, Relaxation and Increased Myocardial Lipid Content: A Multi–Nuclear Spectroscopy Study.

Andrew Apps¹, Justin Lau^1,2, Jack Miller^1,2, Mark Peterzan¹, Andrew Lewis¹, Michael Dodd³, Angus Lau⁴, Ferenc Mozes¹, Oliver Rider¹, Stefan Neubauer¹, and Damian J Tyler^1,2

¹Oxford Centre for Magnetic Resonance Research, Oxford, United Kingdom, ²Department of Physiology, Anatomy and Genetics., University of Oxford, Oxford, United Kingdom, ³School of Life Sciences, Coventry University, Coventry, United Kingdom, ⁴Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada

Hyperpolarised¹³C MRS offers unparalleled opportunities for studying in-vivo, real time metabolism. In our current study we demonstrate how the technique easily demonstrates early pathological changes in PDH flux in the diabetic heart, and is complementary to other spectroscopic and imaging techniques, in defining the metabolic and structural changes characterising the disease.

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