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Abstract #0407

Hyperpolarised 13C MR Spectroscopy Demonstrates Impaired PDH flux In the Diabetic Human Heart, Correlating with Impaired Energetics, Relaxation and Increased Myocardial Lipid Content: A Multi–Nuclear Spectroscopy Study.

Andrew Apps1, Justin Lau1,2, Jack Miller1,2, Mark Peterzan1, Andrew Lewis1, Michael Dodd3, Angus Lau4, Ferenc Mozes1, Oliver Rider1, Stefan Neubauer1, and Damian J Tyler1,2

1Oxford Centre for Magnetic Resonance Research, Oxford, United Kingdom, 2Department of Physiology, Anatomy and Genetics., University of Oxford, Oxford, United Kingdom, 3School of Life Sciences, Coventry University, Coventry, United Kingdom, 4Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada

Hyperpolarised 13C MRS offers unparalleled opportunities for studying in-vivo, real time metabolism. In our current study we demonstrate how the technique easily demonstrates early pathological changes in PDH flux in the diabetic heart, and is complementary to other spectroscopic and imaging techniques, in defining the metabolic and structural changes characterising the disease.

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