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Abstract #0412

Quantitative multi-parametric MRI reveals micro-structural changes in upper-leg muscles after running a marathon

Melissa T. Hooijmans1, Jithsa R.C. Monte2, Martijn Froeling3, Sandra van den Berg-Faay2, Adrianus J. Bakermans2, Vincent L. Aengevaeren4, Mario Maas2, Thijs M.H. Eijsvogels4, Aart J. Nederveen2, and Gustav J. Strijkers1

1Department of Biomedical Engineering and Physics, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands, 2Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands, 3Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 4Radboud Institute for Health Sciences, Department of Physiology, Radboud University Medical Center, Nijmegen, Netherlands

Quantitative MR techniques have shown promise for detection of muscle micro trauma. Muscle injury and recovery involve many pathophysiological processes including, inflammation, regeneration and fibrosis, therefore multi-parametric approaches are critically needed. This study used a multi-parametric quantitative approach to assess micro structural changes in the upper leg muscles after running a marathon on an individual muscle basis as well as on a localized level. Our results indicate that diffusion indices are highly sensitive to detect micro-structural changes on a localized and whole volume basis and that this approach could prove valuable for improved outcome prediction and risk-assessment of sports-related-injuries.

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