Meeting Banner
Abstract #0416

Quantitative MR Relaxation Imaging of Cartilage Compositional Response to Exercise

Dimitri A Kessler1, Joshua D Kaggie1, James W MacKay1, Alexandra R Morgan-Roberts2, Robert L Janiczek3, Martin J Graves1, and Fiona J Gilbert1

1Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 2Independent Clinical Imaging Consultant, Munich, Germany, 3Experimental Medicine Imaging, GlaxoSmithKline, London, United Kingdom

We introduce a method for imaging changes in healthy knee cartilage composition after joint loading with exercise that could be extended for use in subjects with joint disease. Six healthy participants were imaged before and at multiple time-points after a mild joint loading exercise. Our study demonstrates that quantitative MR mapping of T and T2 relaxation times of femorotibial cartilage is repeatable and able to demonstrate changes in cartilage composition in response to short-term joint loading exercise. Imaging cartilage compositional recovery after joint loading may present a new way of detecting early alterations in cartilage homeostasis associated with osteoarthritis.

This abstract and the presentation materials are available to members only; a login is required.

Join Here