Abstract #0417

Quantification of patellofemoral cartilage deformation and contact area changes in response to static loading via high-resolution MRI with prospective motion correction

Thomas Lange¹, Hans Meine^2,3, Elham Taghizadeh^2,3, Benjamin R. Knowles^1,4, Norbert P. Südkamp⁵, Maxim Zaitsev¹, and Kaywan Izadpanah⁵

¹Dept. of Radiology, Medical Physics, Medical Center - University of Freiburg, Freiburg, Germany, ²Department of Informatics, Medical Image Computing Group, University of Bremen, Bremen, Germany, ³Institute for Medical Image Computing, Fraunhofer MEVIS Bremen, Bremen, Germany, ⁴Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁵Department of Orthopedic and Trauma Surgery, Medical Center – University of Freiburg, Freiburg, Germany

Patellofemoral cartilage deformation and contact area changes in response to in situ loading were measured with high-resolution MRI. In situ loading was realized with a pneumatic loading device and motion artifacts were corrected with prospective motion correction based on optical tracking of the knee cap. Semi-automatic cartilage segmentation based on deep learning proved essential for robust quantification of the load-induced changes. Cartilage thickness and contact area showed significant and weight-dependent changes in response to loading. The patellofemoral deformation and contact mechanism under loading might be used for investigation of the knee biomechanics and as a biomarker of early-stage cartilage degeneration.

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