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Abstract #0418

Detecting articular cartilage and meniscus deformations under mechanical load using magnetization transfer ultrashort echo time (MT-UTE) modeling: ex vivo study

Saeed Jerban1, Yajun Ma1, Akhil Kasibhatla1, Jonathan Lee1, Yanjun Chen1, Tan Guo1, Lidi Wan1, Eric Y Chang1,2, and Jiang Du1

1Radiology, University of california, San Diego, San Diego, CA, United States, 2Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States

Ultrashort echo time (UTE) MRI can be used for quantitative assessment of compressive tissues in knee joint such as articular cartilage (AC) and meniscus. In osteoarthritis, the mechanical properties of AC and menisci are altered prior to gross morphological changes. In this study, magnetization transfer UTE imaging (UTE-MT) with two-pool modelling was used to detect deformation levels of AC and meniscus under load. Compression resulted in significant increases of macromolecular fraction (MMF) in AC and menisci of young, but not elderly donors. Our results indicate that biomechanical changes vary with age and can be detected with UTE-MT MRI.

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