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Abstract #0428

Toward quantitative inhomogeneous magnetization transfer (qihMT) using a general Matrix Exponential Model

Andreea Hertanu1, Olivier M. Girard1, Victor N.D. Carvalho1, Lucas Soustelle1, Gopal Varma2, David C. Alsop2, and Guillaume Duhamel1

1Aix Marseille Univ, CNRS, CRMBM UMR 7339, Marseille, France, 2Department of Radiology, Division of MR Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, Boston, MA, United States

Inhomogeneous magnetization transfer is becoming an important tool in the detection of demyelinating pathologies, as well as in the understanding of the molecular mechanisms engaged in demyelinating/remyelinating processes. Although ihMT ratio delivers a reproducible index sensitive to the dipolar order underpinning the ihMT effect, advanced approaches analogous to quantitative MT could allow estimation of quantitative parameters directly related to the underlying biophysical model of myelin. This study proposes a general framework based on the Matrix Exponential Model allowing fast fitting of ihMT data. Demonstration of qihMT is performed ex-vivo on rat spinal cord specimen and in-vivo on mouse brain.

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