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Abstract #0429

Fast Bound Pool Fraction mapping via steady-state MT saturation using single-shot EPI

Marco Battiston1, Torben Schneider2, Francesco Grussu1,3, Marios Yiannakas1, Ferran Prados1,4,5, Claudia A.M. Gandini Wheeler-Kingshott1,6, and Rebecca S. Samson1

1Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, UCL, London, United Kingdom, 2Philips UK, Guilford, United Kingdom, 3Centre for Medical Imaging Computing, Department of Computer Science, UCL, London, United Kingdom, 4Centre for Medical Imaging Computing, Department of Medical Physics and Biomedical Engineering, UCL, London, United Kingdom, 5Universitat Oberta de Catalunya, Barcelona, Spain, 6Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy

The bound pool fraction (BPF) is a quantitative parameter that reflects macromolecular tissue fraction, and has shown sensitivity to myelin content in human white matter. BPF mapping is still largely unexploited for characterizing white matter disease in vivo due to the long MRI protocols needed for its accurate and precise computation. In this work, we develop a new method that allows fast unbiased BPF estimation, suitable for clinical applications.

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