Abstract #0429

Fast Bound Pool Fraction mapping via steady-state MT saturation using single-shot EPI

Marco Battiston¹, Torben Schneider², Francesco Grussu^1,3, Marios Yiannakas¹, Ferran Prados^1,4,5, Claudia A.M. Gandini Wheeler-Kingshott^1,6, and Rebecca S. Samson¹

¹Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, UCL, London, United Kingdom, ²Philips UK, Guilford, United Kingdom, ³Centre for Medical Imaging Computing, Department of Computer Science, UCL, London, United Kingdom, ⁴Centre for Medical Imaging Computing, Department of Medical Physics and Biomedical Engineering, UCL, London, United Kingdom, ⁵Universitat Oberta de Catalunya, Barcelona, Spain, ⁶Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy

The bound pool fraction (BPF) is a quantitative parameter that reflects macromolecular tissue fraction, and has shown sensitivity to myelin content in human white matter. BPF mapping is still largely unexploited for characterizing white matter disease in vivo due to the long MRI protocols needed for its accurate and precise computation. In this work, we develop a new method that allows fast unbiased BPF estimation, suitable for clinical applications.

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