We introduce an artifact reduction technique that exploits the spatial locality afforded by multi-channel receiver array coils. Specifically, we create an optimal coil mixing with the purpose of dampening confounding signals prior to parallel imaging (PI) reconstruction. We demonstrate the mitigation of artifacts caused by PI model inaccuracies for Wave-CAIPI imaging in neurological and MSK applications. In addition, we illustrate the potential of this technique for minimizing the effects of non-rigid maternal and fetal motion during fetal brain imaging. This computationally efficient approach should allow for direct application of model based reconstruction/motion correction methods in difficult imaging scenarios.