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Abstract #0450

Longitudinal Study of Aortic Stiffness and Flow Reversal in Patients with Cryptogenic Stroke

Kelly Jarvis1, Alireza Vali1, Amer Ahmed Syed1, Kathryn Muldoon2, Shyam Prabhakaran2, Jeremy D Collins3, and Michael Markl1

1Radiology, Northwestern University, Chicago, IL, United States, 2Neurology, Northwestern University, Chicago, IL, United States, 3Radiology, Mayo Clinic, Rochester, MN, United States

Atherosclerotic plaque in the descending aorta has emerged as a potential etiology of embolic stroke due to diastolic flow reversal in this region. This study seeks to investigate 1) whether aortic stiffness assessed by pulse wave velocity (PWV) may be related to flow reversal and 2) the effects of medical therapy on PWV and flow reversal. Twenty cryptogenic stroke patients were included in this 4D flow MRI study. We found relationships between age, PWV and flow reversal. No systematic change in PWV or flow reversal was detected for patients taking medications with potential de-stiffening effects.

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