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Abstract #0482

Human Brain 31P NMR Spectra at 7T:  UDP-Glucose Assignment Revisited

Jimin Ren1,2, A Dean Sherry1,2,3, and Craig R Malloy1,2,4

1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 2Department of Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 3Department of Chemistry, University of Texas at Dallas, Richardson, TX, United States, 4VA North Texas Health Care System, Dallas, TX, United States

In a typical human brain 31P NMR spectrum, a small peak is often present at ~-9.7 ppm, near the α-ATP and NAD+/NADH signals. This 31P resonance, accounting for ~1/30th of the brain α-ATP signal, has been considered to be a doublet and assigned to UDPG. Here we present strong evidence to show that the -9.7 ppm signal is in fact a finely structured quartet. This finding has direct impact on current 31P NMR method for evaluation of brain redox, which requires UDPG correction. It may also have implication on our interpretation of brain energy metabolism based on 31P NMR data.

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