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Abstract #0489

Longitudinal structural change in skeletal muscle tissue of Duchenne muscular dystrophy patients based on 1H- and 23Na-MRI

Teresa Gerhalter1,2,3, Lena V. Gast1, Benjamin Marty2,3, Regina Trollmann4, Frank Roemer1, Frederik B. Laun1, Michael Uder1, Pierre G. Carlier2,3, and Armin M. Nagel1

1Institute of Radiology, University Hospital Erlangen, FAU, Erlangen, Germany, 2NMR laboratory, Institute of Myology, Paris, France, 3NMR laboratory, CEA/DRF/IBFJ/MIRCen, Paris, France, 4Department of Pediatrics, Division Neuropediatrics, FAU, Erlangen, Germany

Duchenne muscular dystrophy (DMD) is a hereditary neuromuscular disease leading to progressive muscle wasting. Here, young DMD boys were examined twice within six months with a MRI protocol that included commonly used biomarkers such as fat fraction derived from the Dixon method and water T2 as well as 23Na MRI indices. Sodium anomalies were commonly observed and developed even in absence of fatty degenerative changes and water T2 increases over the observational period. Although limited in the small number of subjects, the data supports that 23Na could be used to characterize early dystrophic muscle alteration in a longitudinal fashion.

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