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Abstract #0492

On the magnetic field dependence of deuterium metabolic imaging (DMI)

Robin A de Graaf1, Arjan D Hendriks2, Dennis W Klomp2, Chathura Kumaragamage1, Dimitri Welting2, Catalina S Arteaga de Castro2, Peter B Brown1, Scott McIntyre1, Terence W Nixon1, Jeanine J Prompers2, and Henk M De Feyter1

1Yale University, New Haven, CT, United States, 2University Medical Center Utrecht, Utrecht, Netherlands

Deuterium metabolic imaging (DMI) is a novel, MR-based method to spatially map metabolism. DMI has been shown to provide robust and sensitive maps of cerebral glucose metabolism in healthy volunteers and patients with brain tumors. Here the magnetic field dependence of DMI in terms of sensitivity and resolution is investigated. Using RF coils sized for animal and human studies on magnetic fields ranging from 4T to 11.7T, a supralinear magnetic field dependence of the DMI sensitivity is established. The increased sensitivity of DMI at 7T compared to 4T allows the acquisition of human brain DMI at a 1 mL spatial resolution.

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