Abstract #0493

Deuterated water labeling followed by deuterium MRI for visualization of tumors in vivo

Nataliya Prokopenko Buxbaum¹, Keita Saito², Hellmut Merkle³, Kathrynne Anelle Warrick⁴, Natella Maglakelidze⁴, Donald Eugene Farthing⁴, Kazu Yamamoto⁵, Nobu Oshima⁶, Murali Krishna Cherukuri⁷, and Ronald Eugene Gress⁴

¹Experimental Transplantation and Immunology Branch (ETIB), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, United States, ²Radiation Biology Branch, NCI, NIH, Bethesda, MD, United States, ³Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD, United States, ⁴ETIB, NCI, NIH, Bethesda, MD, United States, ⁵Radiation Biology Branch (RBB), NCI, NIH, Bethesda, MD, United States, ⁶Urologic Oncology Branch, NCI, NIH, Bethesda, MD, United States, ⁷RBB, NCI, NIH, Bethesda, MD, United States

In vivo DNA labeling with deuterated water (²H₂O) has been used for cell kinetics research and more recently to image rapidly proliferating immune cells in the context of graft-versus-host disease. Using a custom dual-resonance coil (¹H-²H) we demonstrate that this approach can be applied to the in vivo detection of tumors via MRI in a xenograft tumor mouse model. Therefore, this novel imaging technique could serve as a sensitive, safe, and non-radioactive method of tumor detection with significant impact on the field of oncology.

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