We evaluated the accuracy of MR fingerprinting with water and fat separation (MRF-WF) in 22 patients with inclusion body myositis and investigated the potential of water T1 for monitoring disease activity in this inflammatory myopathy characterized by a combination of inflammatory and myodegenerative features. FF and B1 values derived from MRF-WF were highly correlated to reference values and we observed a significant relationship between water T1 and water T2 in the patients. MRF-WF may represent a competitor to the multi-component fitting of MSME data, or to the IDEAL-CPMG method to simultaneously extract biomarkers of disease progression and activity in neuromuscular diseases.
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