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Abstract #0495

Quantification of water T1 and fat fraction in inclusion body myositis using MR fingerprinting with water and fat separation (MRF-WF)

Benjamin Marty1,2, Harmen Reyngoudt1,2, and Pierre G. Carlier1,2

1NMR Laboratory, Institute of Myology, NIC, Paris, France, 2NMR Laboratory, CEA, DRF, IBFJ, MIRCen, Paris, France

We evaluated the accuracy of MR fingerprinting with water and fat separation (MRF-WF) in 22 patients with inclusion body myositis and investigated the potential of water T1 for monitoring disease activity in this inflammatory myopathy characterized by a combination of inflammatory and myodegenerative features. FF and B1 values derived from MRF-WF were highly correlated to reference values and we observed a significant relationship between water T1 and water T2 in the patients. MRF-WF may represent a competitor to the multi-component fitting of MSME data, or to the IDEAL-CPMG method to simultaneously extract biomarkers of disease progression and activity in neuromuscular diseases.

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