Abstract #0499

Increased fatty infiltration of individual extraocular muscles in myasthenia gravis and graves’ orbitopathy

Kevin Keene¹, Luc Van Vught², Isabeau Ciggaar², Irene Notting³, Stijn Genders³, Jan Verschuuren⁴, Martijn Tannemaat⁴, Hermien Kan⁵, and Jan-Willem Beenakker²

¹Neurology and Radiology, CJ Gorter center for high field MRI, Leiden University Medical Center, Leiden, Netherlands, ²Ophthalmology and radiology, CJ Gorter center for high field MRI, Leiden University Medical Center, Leiden, Netherlands, ³Ophthalmology, Leiden University Medical Center, Leiden, Netherlands, ⁴Neurology, Leiden University Medical Center, Leiden, Netherlands, ⁵Radiology, CJ Gorter center for high field MRI, Leiden University Medical Center, Leiden, Netherlands

We explored the feasibility of 7 Tesla quantitative MRI for quantifying fat fraction and muscle volume of individual extraocular muscles in myasthenia gravis (MG) and Graves’ orbitopathy (GO) patients and healthy controls. The Dixon scans show a high reproducibility for individual extraocular muscles. The fat fractions are higher in MG and GO patients than in healthy controls. Quantitative MRI of individual extraocular muscles may provide a first step to understand the pathophysiology and pattern of muscle involvement of the eyes in MG and GO patients.

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