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Abstract #0500

Dextran-based CEST MRI for detecting extradomain-B fibronectin in pancreatic cancer

Jiaqi Lu1, Zheng Han2, Jia Zhang2, Yuguo Li2, Jing Liu2, Kenji Fujiwara3, Peter van Zijl2, Lei Zhang3, and Guanshu Liu2,4

1Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, United States, 2Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, 3Department of Oncology, Johns Hopkins University, Baltimore, MD, United States, 4F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institue, Baltimore, MD, United States

A dextran-peptide conjugate was developed for MR molecular imaging of pancreatic ductal adenocarcinoma (PDAC) through its overexpressed microenvironment biomarker, extradomain-B fibronectin (EDB-FN). Dextrans can be directly detected by chemical exchange saturation transfer (CEST) MRI without the need for radionuclide- or metallic labeling. In addition, large molecular weight dextran, dextran 10 (MW~ 10 kD), provides an approximately fifty times higher sensitivity per molecule than a single glucose unit. The potential of this highly biocompatible diamagnetic probe is demonstrated in a murine syngeneic allograft PDAC tumor model.

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