Abstract #0501

Multi-Parametric MRI assessment of pulsed focused ultrasound treated pancreas tumor

Ezekiel Maloney¹, Yak-Nam Wang², Ravneet Vohra¹, Tatiana Khohklova³, Stella Whang³, Helena Son³, Joshua Park¹, Kayla Gravelle³, Yasser Hussaini¹, Stephanie Totten³, Joo Ha Hwang^3,4, and Donghoon Lee¹

¹Department of Radiology, University of Washington, Seattle, WA, United States, ²Applied Physics Laboratory, University of Washington, Seattle, WA, United States, ³Division of Gastroentrology, University of Washington, Seattle, WA, United States, ⁴Department of Medicine, Stanford, Stanford, CA, United States

Pancreatic ductal adenocarcinoma (PDA) is characterized by excessive levels of hyaluronan and collagen, resulting in a dense fibroinflammatory stroma that inhibits penetration of chemotherapeutic drugs into the tumor. Pulsed focused ultrasound (pFUS) treatment has shown promising results in disrupting the dense stroma and reducing the interstitial fluid pressure of PDA. The purpose of this study is to noninvasively assess response to pFUS treatments using quantitative MRI and to correlate the MRI results with histopathology data.

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