Abstract #0502

Dynamic Oxygen-Enhanced MRI (dOE-MRI) with group ICA detects increased oxygenation in murine tumours treated with VEGF-ablation therapy

Firas Moosvi¹, Jennifer H.E. Baker², Andrew Yung³, Piotr Kozlowski³, Andrew I. Minchinton⁴, and Stefan A. Reinsberg⁵

¹Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, ²Oncology, BC Cancer Research Centre, Vancouver, BC, Canada, ³UBC MRI Research Centre, Vancouver, BC, Canada, ⁴BC Cancer Research Centre, Vancouver, BC, Canada, ⁵University of British Columbia, Vancouver, BC, Canada

Tumours treated with VEGF ablation sustain changes to their vasculature, which can result in tissue oxygenation changes. This work uses dynamic oxygen enhanced MRI (dOE-MRI) to assess oxygenation of murine SCCVII tumours treated with B20-4.1.1 (murine anti-VEGF antibody) relative to controls. T1-weighted parameter maps and a modified ICA quantitative analysis technique, groupICA, describe an increase in B20-treated tumour oxygenation.

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