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Abstract #0503

Dynamic OE-MRI Mapping of Lung Parenchymal Radiotherapy Effects in Non-Small Cell Lung Cancer Patients

Michael J Dubec1,2,3, Ahmed Salem2,3, Yvonne Watson1, Ross Little1, Corinne Faivre-Finn2,3, Julian Matthews4, Marcel van Herk2,3, James PB O'Connor1,2,3, and Geoff JM Parker1,4,5

1Quantitative Biomedical Imaging Laboratory, University of Manchester, Manchester, United Kingdom, 2Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom, 3The Christie NHS Foundation Trust, Manchester, United Kingdom, 4Division of Neuroscience and Experimental Psychology, University of Manchester, Manchester, United Kingdom, 5Bioxydyn Limited, Manchester, United Kingdom

Radiation induced lung disease (RILD) can occur following thoracic irradiation, chemotherapy and immunotherapy in lung cancer patients, manifesting as inflammation, radiation pneumonitis or fibrosis. Oxygen Enhanced (OE)-MRI provides spatial information on oxygen delivery to lung tissue. Five non-small cell lung cancer patients underwent OE-MRI pre and post radiotherapy. Statistically significant changes were measured between pre and post radiotherapy scans in both the contralateral and ipsilateral lungs. These findings indicate that OE-MRI can assess changes in lung function following radiotherapy, with potential application for personalised therapy and reduction of toxicity.

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