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Abstract #0507

Identification of early stage murine pancreatic tumors by a combinatorial approach employing SPEN DWI, FLAIR T1 and hyperpolarized 13C MRI

Ricardo P. Martinho1, Qingjia Bao1, Stefan Markovic1, Dina Preise2, Keren Sasson2, Avigdor Scherz2, and Lucio Frydman1

1Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel, 2The Moross Integrated Cancer Research Center, Weizmann Institute of Science, Rehovot, Israel

Pancreatic ductal adenocarcinoma has a poor prognosis. This study explored the use of a multimodal screening approach on a preclinical mouse PDAC model that included T1 and T2 mapping, SPatiotemporal ENcoding (SPEN) and EPI-based DWI, and MT methods, and hyperpolarized 13C metabolic MRSI, to follow the progress of the disease from early on. Whereas T2 and MT were of little help, markedly decreased diffusivity, extended T1s and significantly higher metabolic activities could be detected for large and small tumors alike. These approaches could provide a translatable approach to the early noninvasive detection of pancreatic cancer, leading to timely treatment.

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