Pancreatic ductal adenocarcinoma has a poor prognosis. This study explored the use of a multimodal screening approach on a preclinical mouse PDAC model that included T1 and T2 mapping, SPatiotemporal ENcoding (SPEN) and EPI-based DWI, and MT methods, and hyperpolarized 13C metabolic MRSI, to follow the progress of the disease from early on. Whereas T2 and MT were of little help, markedly decreased diffusivity, extended T1s and significantly higher metabolic activities could be detected for large and small tumors alike. These approaches could provide a translatable approach to the early noninvasive detection of pancreatic cancer, leading to timely treatment.
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