Abstract #0508

Characterization of metabolic adaptations of patient-derived xenografts to in vitro tissue and cell culture using high-resolution NMR

Jinny Sun¹, Jeffrey Hsiao¹, Justin Delos Santos¹, Robert Bok¹, Hongjuan Zhao², Jeremy Bancroft Brown¹, James Brooks², John Kurhanewicz¹, Donna Peehl¹, and Renuka Sriram¹

¹Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Urology, Stanford University, Stanford, CA, United States

In this study we investigated the metabolic changes that occurred when a renal cell carcinoma patient-derived xenograft was propagated in tissue slice culture or primary cell culture at varying pO₂ levels to understand the attributes and limitations of each of the model systems for studying the metabolic underpinnings of this pathology using high resolution NMR. This data indicates drastically altered metabolism at varying pO₂ and between each model system.

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