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Abstract #0508

Characterization of metabolic adaptations of patient-derived xenografts to in vitro tissue and cell culture using high-resolution NMR

Jinny Sun1, Jeffrey Hsiao1, Justin Delos Santos1, Robert Bok1, Hongjuan Zhao2, Jeremy Bancroft Brown1, James Brooks2, John Kurhanewicz1, Donna Peehl1, and Renuka Sriram1

1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Urology, Stanford University, Stanford, CA, United States

In this study we investigated the metabolic changes that occurred when a renal cell carcinoma patient-derived xenograft was propagated in tissue slice culture or primary cell culture at varying pO2 levels to understand the attributes and limitations of each of the model systems for studying the metabolic underpinnings of this pathology using high resolution NMR. This data indicates drastically altered metabolism at varying pO2 and between each model system.

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