We studied tumour Apparent Diffusion Coefficient (ADC), necrosis and cellularity in untreated rodent tumours of twelve types from six centres using two different vendors’ equipment. Tumour types included human xenografts (conventional and patient-derived) genetically engineered mouse tumours and syngeneic rat tumours. Across this broad spectrum there was a robust inverse correlation between ADC and cellularity, and a weaker positive correlation between ADC and necrosis. ADC mean and median were the best correlates for cellularity, while ADC standard deviation and kurtosis provided the best correlates for necrosis. This work advances the biological validation of ADC as a biomarker of tumour cellularity.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords