Abstract #0510

Simultaneous linear-combination modeling of MEGA-PRESS sum and difference spectra without soft constraints

Georg Oeltzschner^1,2, Gašper Zupan³, and Richard A. E. Edden^1,2

¹Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Institute of Pathophysiology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia

J-difference edited magnetic resonance spectroscopy is widely used to estimate levels of low-concentration metabolites with overlapping signals. Quantification is commonly performed on the difference spectra only, either using single-resonance fitting or linear-combination modeling based on simulated basis functions. Here, simultaneous linear-combination modeling of GABA-edited MEGA-PRESS sum and difference spectra is demonstrated. Simultaneous modeling incorporates all available spectral information, and does not require the definition of soft constraints on the low-concentration metabolite estimates. Across a large dataset, this new approach gave lower coefficients of variation for estimates of GABA, glutamate, and glutamine than modeling of the difference and sum spectra only.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.