The temporal pattern of spinal cord (SC) tissue changes in Neuromyelitis optica spectrum disorder, a rare neuro-inflammatory condition, was evaluated for the first time using a multi-parametric MR protocol covering the whole cervical SC (high-resolution T2*-weighted anatomical imaging, diffusion tensor imaging (DTI), 3D-MP2RAGE T1-mapping, conventional and inhomogeneous Magnetization Transfer (MT/ihMT) imaging). Results showed substantial pathological variations of all MR metrics at baseline in agreement with the presence of a multi-level inflammatory lesion and a temporal pattern suggesting progressive recovery to control values, with T1 values being the most sensitive to temporal changes and showing residual tissue destructuration following the myelitis.
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