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Abstract #0522

An exploratory study to evaluate the potentiality of advanced multi-parametric MRI for longitudinal follow-ups of patients with Neuromyelitis optica spectrum disorder

Henitsoa Rasoanandrianina1,2, Bertrand Audoin1,2,3, Aurélien Massire1,2, Lauriane Pini1,2, Claire Coste1,2, Maxime Guye1,2, Romain Marignier4, and Virginie Callot1,2

1Aix-Marseille Université, CNRS, CRMBM, Marseille, France, 2AP-HM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, 3Department of Neurology, CHU Timone, AP-HM, Marseille, France, 4Department of Neurology, CHU Lyon, Hôpital Pierre Wertheimer, Lyon, France

The temporal pattern of spinal cord (SC) tissue changes in Neuromyelitis optica spectrum disorder, a rare neuro-inflammatory condition, was evaluated for the first time using a multi-parametric MR protocol covering the whole cervical SC (high-resolution T2*-weighted anatomical imaging, diffusion tensor imaging (DTI), 3D-MP2RAGE T1-mapping, conventional and inhomogeneous Magnetization Transfer (MT/ihMT) imaging). Results showed substantial pathological variations of all MR metrics at baseline in agreement with the presence of a multi-level inflammatory lesion and a temporal pattern suggesting progressive recovery to control values, with T1 values being the most sensitive to temporal changes and showing residual tissue destructuration following the myelitis.

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