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Abstract #0523

Reproducibility of Quantitative Cervical Spinal Cord MRI for Multi-center Clinical Trials in Multiple Sclerosis

Joo-won Kim1, Haocheng Cai2, Mohamed Mounir El Mendili1, Peng Sun3, Courtney Dula3, Christina Alfonso1, Sheng-Kwei Song3, Matilde Inglese1, Robert T Naismith3, and Junqian Xu1

1Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Touro college of osteopathic medicine, New York, NY, United States, 3Washington University in St. Louis, St. Louis, MO, United States

Quantitative cervical spinal cord (C-spine) MRI offers promising biomarkers for progressive multiple sclerosis (MS). The intra- and inter-site, short- and long-term reproducibility of these quantitative C-spine MRI measurements is crucial for designing longitudinal or multi-site study. In this two-site pilot study, we evaluated the reproducibility of quantitative C-spine MRI and demonstrate the feasibility of multi-site study with high reproducibility using a harmonized protocol.

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