Abstract #0523

Reproducibility of Quantitative Cervical Spinal Cord MRI for Multi-center Clinical Trials in Multiple Sclerosis

Joo-won Kim¹, Haocheng Cai², Mohamed Mounir El Mendili¹, Peng Sun³, Courtney Dula³, Christina Alfonso¹, Sheng-Kwei Song³, Matilde Inglese¹, Robert T Naismith³, and Junqian Xu¹

¹Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Touro college of osteopathic medicine, New York, NY, United States, ³Washington University in St. Louis, St. Louis, MO, United States

Quantitative cervical spinal cord (C-spine) MRI offers promising biomarkers for progressive multiple sclerosis (MS). The intra- and inter-site, short- and long-term reproducibility of these quantitative C-spine MRI measurements is crucial for designing longitudinal or multi-site study. In this two-site pilot study, we evaluated the reproducibility of quantitative C-spine MRI and demonstrate the feasibility of multi-site study with high reproducibility using a harmonized protocol.

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