We recently demonstrated that resting-state fMRI (rsfMRI) network dynamics can be mapped with voxel-resolution in the mouse, and that oscillatory state transitions govern rsfMRI network dynamics in the resting mouse brain. Here we show that pharmacological modulation of cholinergic activity strongly affects the spatio-temporal dynamics of rsfMRI state fluctuations, encompassing novel spatial topographies and altered spatio-temporal dynamics. Our results implicate ascending cholinergic activity in the generation of oscillating fMRI states in the resting brain.
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