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Abstract #0532

Pharmacological stimulation of cholinergic activity alters brain-wide spontaneous fMRI network dynamics

Daniel Gutierrez-Barragan1,2, Carola Canella2,3, Alberto Galbusera3, Stefano Panzeri1, and Alessandro Gozzi3

1Neural Computation Laboratory, Istituto Italiano di Tecnologia, Center for Neuroscience and Cognitive Systems @ UNITN, Rovereto, Italy, 2CIMeC, Center for Mind/Brain Sciences, University of Trento, Rovereto, Italy, 3Functional Neuroimaging Laboratory, Istituto Italiano di Tecnologia, Center for Neuroscience and Cognitive Systems @ UNITN, Rovereto, Italy

We recently demonstrated that resting-state fMRI (rsfMRI) network dynamics can be mapped with voxel-resolution in the mouse, and that oscillatory state transitions govern rsfMRI network dynamics in the resting mouse brain. Here we show that pharmacological modulation of cholinergic activity strongly affects the spatio-temporal dynamics of rsfMRI state fluctuations, encompassing novel spatial topographies and altered spatio-temporal dynamics. Our results implicate ascending cholinergic activity in the generation of oscillating fMRI states in the resting brain.

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