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Abstract #0533

Modulation of resting-state functional MRI signal by astrocyte

Akira Sumiyoshi1,2, Satoshi Ikemoto1, Elliot A. Stein1, Yihong Yang1, and Hanbing Lu1

1National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, United States, 2National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan

Although resting-state functional MRI (rs-fMRI) is extensively used to study brain circuitry, recent animal studies suggest a non-neuronal origin of the rs-fMRI signal. We hypothesized that astrocytes may play an important role in rs-fMRI signal. We used chemogenetic technology to selectively activate astrocytes (increasing Ca2+ levels) and recorded rs-fMRI signals in lightly anesthetized rats. Chemogenetic activation of astrocytes following 0.1 mg/kg of clozapine injection induced signal intensity changes and reduced functional connectivity. These in vivo results are consistent with previous brain slice studies, confirming a potentially important role of astrocytes in rs-fMRI signals.

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