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Abstract #0534

Negative BOLD responses in the rat visual pathway

Rita Gil1, Francisca Fernandes1, Clémence Ligneul1, and Noam Shemesh1

1Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal

Negative BOLD responses (NBRs) in the rat visual cortex (VC) are reported, for the first time, upon high frequency visual stimulation. So far, in rats, only an attenuation of the positive BOLD response (PBR) in VC had been reported with increase of the stimulus frequency up to 10-12Hz1,2. Here, experiments with very high sensitivity thanks to a cryoprobe operating at 9.4T, reveal NBRs in VC and how they are modulated by hyperoxia (already reported for PBRs3,4). Results suggest the possibility that the neurovascular couplings operating under PBRs and NBRs might not be the same.

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