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Abstract #0537

Prospects for improving neuronal specificity of fMRI with Ferumoxytol: an evaluation of vascular segmentation and cortical depth-dependent analysis

Michaƫl Bernier1,2, Jingyuan E. Chen1,2, Ned Ohringer1, Nina E. Fultz1, Rebecca Karp Leaf3, Olivia Viessmann1,2, Laura D. Lewis1,2, Lawrence L. Wald1,2,4, and Jonathan R. Polimeni1,2,4

1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, MA, United States, 2Department of Radiology, Harvard Medical School, Boston, MA, United States, 3Division of Hematology, Massachusetts General Hospital, Boston, MA, United States, 4Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, MA, United States

Ferumoxytol, a superparamagnetic iron oxide nanoparticle, is commonly used as an intravenous treatment for anemia, but has been recently employed as a blood-pool contrast agent for MRI. Here we evaluated Ferumoxytol as a tool to improve the neuronal specificity of fMRI using it for both improved vascular segmentation and for CBV-weighted functional contrast. We employed multi-echo gradient recalled echo (ME-GRE) acquisitions with functional imaging pre and post injection, performed vascular extraction/segmentation, and report apparent quantitative CBV changes surrounding vessels as a function of echo-time. This work demonstrates the possibility of high-resolution CBV mapping, gray- and white-matter angiography, and cortical depth-dependent analyses with this contrast agent.

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