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Abstract #0538

Hyperoxia calibrated fMRI for dynamic mapping of CMRO2 responses using MR-based measurements of whole-brain Yv: Comparison to standard calibration models and measurement of CMRO2 response to finger tapping

Erin K Englund1, Maria A Fernandez-Seara2, Ana E Rodriguez-Soto1, Hyunyeol Lee1, John A Detre3, Zachary B Rodgers1, and Felix W Wehrli1

1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Department of Radiology, University of Navarra, Pamplona, Spain, 3Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States

The magnitude of neurometabolic responses to stimuli can be quantified using calibrated fMRI. Here we compare existing calibration models to Yv-based calibration. The Yv-based calibration model measures whole-brain venous oxygen saturation in the superior sagittal sinus along with BOLD changes and ASL-measured CBF changes to derive maps of the calibration constant, M, in response to a hyperoxia stimulus. M-maps were compared between the proposed and existing calibration models. Then, relative CMRO2 changes in response to a finger tapping task were computed based on the derived M-maps. A ~19% increase in CMRO2 in the motor cortex was observed.

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