The magnitude of neurometabolic responses to stimuli can be quantified using calibrated fMRI. Here we compare existing calibration models to Yv-based calibration. The Yv-based calibration model measures whole-brain venous oxygen saturation in the superior sagittal sinus along with BOLD changes and ASL-measured CBF changes to derive maps of the calibration constant, M, in response to a hyperoxia stimulus. M-maps were compared between the proposed and existing calibration models. Then, relative CMRO2 changes in response to a finger tapping task were computed based on the derived M-maps. A ~19% increase in CMRO2 in the motor cortex was observed.