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Abstract #0539

Non-contrast assessment of BBB permeability using WEPCAST MRI: validation with contrast-agent based method

Zixuan Lin1,2, Jinsoo Uh3, Yang Li1, Dengrong Jiang1,2, and Hanzhang Lu1,2

1Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, 2Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, 3Department of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, TN, United States

Water-extraction-with-phase-contrast-arterial-spin-tagging (WEPCAST) MRI was recently proposed for non-contrast assessment of blood-brain barrier (BBB) permeability to water. However, this approach has not been directly compared with contrast-based method. In this study, we used Gd-based MRI method to validate the WEPCAST MRI. Two methods provide consistent results, suggesting that WEPCAST MRI has a potential to become an alternate to clinical contrast-based BBB permeability assessment.

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