Abstract #0539

Non-contrast assessment of BBB permeability using WEPCAST MRI: validation with contrast-agent based method

Zixuan Lin^1,2, Jinsoo Uh³, Yang Li¹, Dengrong Jiang^1,2, and Hanzhang Lu^1,2

¹Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, ²Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, ³Department of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, TN, United States

Water-extraction-with-phase-contrast-arterial-spin-tagging (WEPCAST) MRI was recently proposed for non-contrast assessment of blood-brain barrier (BBB) permeability to water. However, this approach has not been directly compared with contrast-based method. In this study, we used Gd-based MRI method to validate the WEPCAST MRI. Two methods provide consistent results, suggesting that WEPCAST MRI has a potential to become an alternate to clinical contrast-based BBB permeability assessment.

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