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Abstract #0543

Hemodynamic imaging in brain tumors using dextran1-enhanced CEST MRI

Chuheng Chen1, Zheng Han2, Xiang Xu2,3, Renyuan Bai4, Verena Staedtke4, Jiadi Xu2,3, Linda Knutsson2,5, Peter van Zijl2,3, and Guanshu Liu2,3

1Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, 2Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, 3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 4Department of Oncology, Johns Hopkins University, Baltimore, MD, United States, 5Department of Medical Radiation Physics, Lund University, Lund, Sweden

Sugar-based compounds have shown potential as biodegradable contrast agents for cancer detection. Recently, a multi-size dextran MRI approach was developed for detecting permeability-related properties in tumors. Here, we explored a small size dextran, dextran1 (MW~ 1 kD), as a new MRI contrast agent for detecting brain tumor hemodynamic properties including blood–brain barrier (BBB) breakdown and cerebral blood volume. Our results demonstrate that dextran1 has great potential in indicating BBB integrity, which is confirmed by dynamic contrast-enhanced (DCE) MRI and histology findings. Importantly, contrary to D-glucose, dextran1 does not enter the CSF, removing a source of interfering background signal that is present in dynamic glucose-enhanced (DGE) MRI.

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