Abstract #0544

Imaging injectable liposomal hydrogels using CEST MRI for applications in the brain

Xiongqi Han¹, Jianpan Huang¹, Peng Xiao¹, Joseph Ho Chi Lai¹, and Kannie Wai Yan Chan^1,2,3

¹City University of Hong Kong, Hong Kong, China, ²Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States

Nanocarrier-loaded hydrogel shows good prospects in biomedical application. However, there is lack of noninvasive methods for real time monitoring to guide therapy. Here, we developed a CEST-nanosensor incorporated injectable hydrogel using two most commonly used hydrogel (alginate, and hyaluronan-methylcellulose (HAMC)) and liposomes. Both hydrogels showed storage modulus (G’) comparable to native brain tissue and good injectabilities. Moreover, we observed that our LipoCEST hydrogels generate unique CEST contrasts at 5 ppm (barbituric acid (BA), drug) and -3.4 ppm (liposomes) on 3T, facilitating the multicolor CEST imaging and imaging-guided therapy in brain applications.

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