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Abstract #0547

Detection of abnormal glucose uptake and metabolism in perinatal hypoxia using glucoCEST MRI

Tsang-Wei Tu1, Chao-Hsiung Hsu1, Tirone Johnson2, Paul Wang1, and Joseph Scafidi2

1Howard University, Washington, DC, United States, 2Children's National Medical Center, Washington, DC, United States

Perinatal brain injury, such as perinatal hypoxia from chronic lung disease, results in devastating, neurologic impairment. The immediate and long-term effects on brain energy metabolism of glucose – a major source of energy for the brain - are not known. Previous studies have shown that perinatal brain injury from perinatal hypoxia results in long-term decreases in neuronal oxidative metabolism of glucose and decreased synthesis of N-acetylaspartate. In this study, we utilized dynamic glucoCEST enhancement MRI to investigate the pattern of glucose uptake and metabolism between the mice of normoxic and hypoxic treatment.

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