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Abstract #0548

Saturation transfer of relayed nuclear Overhauser enhancement: its relationship with the chemical exchange

Tao Jin1, Julius Chung2,3, and Seong-Gi Kim2

1University of Pittsburgh, Pittsburgh, PA, United States, 2Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Korea, Republic of, 3Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Suwon, Korea, Republic of

In saturation transfer experiments, the Nuclear Overhauser enhancement (NOE) is often detected from mobile macromolecules and is usually assumed through an exchange-relayed pathway. However, the relationship of such relayed-NOE signals with the chemical exchange is still unclear. We reported simulation, phantom and in vivo studies to examine the dependence of relayed-NOE signal on the chemical exchange.

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