Abstract #0548

Saturation transfer of relayed nuclear Overhauser enhancement: its relationship with the chemical exchange

Tao Jin¹, Julius Chung^2,3, and Seong-Gi Kim²

¹University of Pittsburgh, Pittsburgh, PA, United States, ²Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Korea, Republic of, ³Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Suwon, Korea, Republic of

In saturation transfer experiments, the Nuclear Overhauser enhancement (NOE) is often detected from mobile macromolecules and is usually assumed through an exchange-relayed pathway. However, the relationship of such relayed-NOE signals with the chemical exchange is still unclear. We reported simulation, phantom and in vivo studies to examine the dependence of relayed-NOE signal on the chemical exchange.

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