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Abstract #0549

Quantitative Magnetization Transfer Detects Renal Fibrosis in Swine Kidney with Renal Artery Stenosis

Kai Jiang1, Christopher M. Ferguson1, John R. Woollard1, James D. Krier1, Xiangyang Zhu1, and Lilach O. Lerman1

1Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, United States

Quantitative magnetization transfer (qMT) was used on swine kidneys with renal artery stenosis (RAS). The reproducibility of qMT at 1.5 and 3.0 T was tested in two RAS pigs and its utility in measuring renal fibrosis investigated in seven pigs at 3.0 T by comparing to histology. The Henkelman-Ramani equation was used to derive the bound pool fraction f. Comparable f values were obtained at 1.5 and 3.0 T. Measured f also correlated well with renal fibrosis by histology. In conclusion, qMT is reproducible at different field strengths and can be used to measure renal fibrosis in swine with RAS.

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