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Abstract #0608

Measuring layer-dependent fMRI activity across layers in cognitive brain areas: challenges and capabilities

Laurentius Huber1, Emily Finn1, David Jangraw1, and Peter Bandettini1

1NIH, Bethesda, MD, United States

While recent advances in high-resolution fMRI allow for investigating activity across cortical layers, applications beyond the well-studied primary sensory and primary motor areas have been complicated by multiple technical challenges: lack of anatomical landmarks, complicated folding structure, weak signal, restricted task design, etc. The purpose of this study is to develop a scanning/stimulation/analysis setup that allows us to overcome these challenges. Our results suggest that with advanced imaging methodology, corresponding task design, and appropriate analysis strategies it is possible to reliably measure layer-dependent activity differences in cognitive brain areas, such as the dorsolateral prefrontal cortex.

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