While recent advances in high-resolution fMRI allow for investigating activity across cortical layers, applications beyond the well-studied primary sensory and primary motor areas have been complicated by multiple technical challenges: lack of anatomical landmarks, complicated folding structure, weak signal, restricted task design, etc. The purpose of this study is to develop a scanning/stimulation/analysis setup that allows us to overcome these challenges. Our results suggest that with advanced imaging methodology, corresponding task design, and appropriate analysis strategies it is possible to reliably measure layer-dependent activity differences in cognitive brain areas, such as the dorsolateral prefrontal cortex.
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