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Abstract #0609

Laminar CBF and BOLD fMRI in the human visual cortex using arterial spin labelling at 7T

Sriranga Kashyap1, Dimo Ivanov1, Martin Havlicek1, Benedikt A Poser1, and Kamil Uludag1,2

1Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands, 2Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of

Laminar fMRI at ultra-high field is typically carried out using the BOLD contrast. Despite its unrivalled sensitivity, the BOLD contrast is limited in its spatial specificity (e.g. due to intracortical ascending and pial veins). Alternatively, the regional change in cerebral blood flow (CBF), is a quantitative measure directly related to neuronal activation. However, CBF fMRI with high spatial resolution is challenging due to the relatively lower SNR. Building on previous work, we demonstrate for the first time, sub-millimetre spatial resolution simultaneous CBF and BOLD acquisition using arterial spin labelling (ASL) for laminar fMRI at 7T.

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