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Abstract #0610

A Novel Intravascular Contrast for Laminar Functional MRI

Yuhui Chai1, Linqing Li2, Laurentius Huber1, and Bandettini Peter1,2

1Section on Functional Imaging Methods, NIMH, Bethesda, MD, United States, 2Functional MRI Core, NIMH, Bethesda, MD, United States

In this work, we proposed a novel intravascular contrast for laminar specific fMRI in the human brain at 7T. This technique was shown to be sensitive to both cerebral blood volume (CBV) and flow (CBF) changes. We demonstrate that this new tool, with its highly specified functional layer profile, robust reproducibility and improved sensitivity, allows neuroscientific investigation of information flow across cortical microcircuits.

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