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Abstract #0611

Concurrent intracellular calcium recordings with laminar fMRI mapping

Hang Zeng1,2, Sangcheon Choi1,2, Filip Sobczak1,2, Bruce Rosen3, and Xin Yu2,3

1Graduate Training Centre of Neuroscience, International Max Planck Research School, University of Tuebingen, Tübingen, Germany, 2Magnetic Resonance Department, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 3MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, USA., Boston, MA, United States

The ultra-high magnetic field strengths of 14.1T allows visualization of laminar-specific neurovascular coupling events with fMRI in living animals. Combining line-scanning fMRI and intracellular calcium signal recording, we present laminar-specific coupling features at high temporal and spatial resolution along the cortical thickness, showing strong Layer 4 fMRI correlation to the calcium signal and largely varied coupling features from adjacent cortices in the anesthetized rats.

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