Abstract #0611

Concurrent intracellular calcium recordings with laminar fMRI mapping

Hang Zeng^1,2, Sangcheon Choi^1,2, Filip Sobczak^1,2, Bruce Rosen³, and Xin Yu^2,3

¹Graduate Training Centre of Neuroscience, International Max Planck Research School, University of Tuebingen, Tübingen, Germany, ²Magnetic Resonance Department, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, ³MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, USA., Boston, MA, United States

The ultra-high magnetic field strengths of 14.1T allows visualization of laminar-specific neurovascular coupling events with fMRI in living animals. Combining line-scanning fMRI and intracellular calcium signal recording, we present laminar-specific coupling features at high temporal and spatial resolution along the cortical thickness, showing strong Layer 4 fMRI correlation to the calcium signal and largely varied coupling features from adjacent cortices in the anesthetized rats.

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