Abstract #0612

Whole brain depth-dependent task based connectivity with laminar fMRI

Daniel Sharoh¹, Tim van Mourik¹, Lauren J. Bains¹, Katrien Segaert², Kirsten Weber^1,3, Peter Hagoort^1,3, and David G. Norris^1,4,5

¹Donders Institute, Nijmegen, Netherlands, ²Department of Psychology, University of Birmingham, Birmingham, United Kingdom, ³Max Planck Institute for Psycholinguistics, Nijmegen, Netherlands, ⁴Erwin L. Hahn Institute for MRI, Universität Duisburg-Essen, Essen, Germany, ⁵Faculty of Science and Technology, University of Twente, Twente, Netherlands

Laminar resolution, functional magnetic resonance imaging (lfMRI) is a noninvasive technique with the potential to distinguish top-down and bottom-up signal contributions on the basis of depth-dependent interactions with distal regions. Hitherto, lfMRI has not been used to investigate whole-brain distributed networks nor complex cognitive tasks. We show here that lfMRI can reveal whole-brain directed networks during word reading. We identify language critical regions based on their association with the top-down signal stream and herewith establish lfMRI for the non-invasive assessment of directed connectivity.

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