Abstract #0617

High-resolution fMRI maps of columnar organization in human primary somatosensory cortex

Jiajia Yang^1,2, Laurentius Huber², Yinghua Yu^1,2,3, Yuhui Chai², Arman Khojandi², and Peter A Bandettini^2,4

¹Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Okayama, Japan, ²Section on Functional Imaging Methods, National Institute of Mental Health, Bethesda, MD, United States, ³The Japan Society for the Promotion of Science, Tokyo, Japan, ⁴Functional MRI Core Facility, National Institute of Mental Health, Bethesda, MD, United States

More than half a century ago, animal studies revealed that area 3b of the primary somatosensory cortex (S1) receives cutaneous input from slow-adapting (SA) and rapidly adapting (RA) cutaneous receptors in a columnar manner. However, there have been no direct observations of columnar origination in the human SI. Here, for the first time, we investigate the columnar organization in the human S1 by using advanced high-resolution (0.7mm) fMRI at 7T. We find that the human area 3b is columnar organized with alternating SA and RA columnar preferences. We find that SA selective stimulation evokes activity in the middle layers only.

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