Abstract #0623

Tau Propagation Pattern Is Suggested Through Associations with Structural Tract Alterations: A Data Driven Approach

Qiuting Wen¹, Shannon L. Risacher¹, Sourajit M. Mustafi¹, Jaroslaw Harezlak², Linhui Xie¹, John D. West¹, Martin R. Farlow¹, Frederick W. Unverzagt¹, Liana G. Apostolova¹, Andrew J. Saykin¹, and Yu-Chien Wu¹

¹Indiana University, School of Medicine, Indianapolis, IN, United States, ²Department of Epidemiology and Biostatistics, Indiana University, School of Public Health, Bloomington, IN, United States

To test the hypothesis that the propagation of tau is facilitated by microstructural alterations in white-matter tracts, we applied a data driven approach to study the “upstream tau – tract alteration – downstream tau” associations throughout the whole brain using tau positron emission tomography (tau-PET) and diffusion MRI (dMRI). The discovered pathways of spread support the characteristic pattern observed in Braak staging.

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