This study aims to investigate the topological
organization in T2DM with and without impairment, and characterize its
relationships with clinical measurements. Forty T2DM patients were divided into
two sub-groups(impaired and normal cognition), together with ten healthy
controls, were imaged at a 3T scanner. We found that the T2DM patients with
cognitive impairment had decreased global efficiency, local efficiency, but
increased shortest path length than those with normal cognition and healthy controls.
Decreased nodal properties were also detected. Decreased clustering
coefficients correlated with the neuropsychological assessment and disease
duration. The structural topological properties research shows potential
feasibility in characterizing intrinsic alterations of diabetic encephalopathy.