Abstract #0625

White Matter Damage of Alzheimer’s Disease using Magnetization Transfer Imaging

Wenna Duan¹, Parshant Sehrawat¹, James T. Becker², Oscar L. Lopez³, H. Michael Gach⁴, and Weiying Dai¹

¹Department of Computer Science, State University of New York at Binghamton, Binghamton, NY, United States, ²Department of Psychology, University of Pittsburgh, Pittsburgh, PA, United States, ³3. Department of Psychiatry and Neurology, University of Pittsburgh, Pittsburgh, PA, United States, ⁴Department of Radiation Oncology, Washington University, Saint Louis, WA, United States

The magnetization transfer rate has not been widely used as a biomarker for Alzheimer’s disease (AD). In this study, we measured the magnetization transfer rates in the cardiovascular health study (CHS) cognition study (CHS-CS) cohort at 1.5 T by acquiring T1 maps with and without off-resonance saturation. The magnetization transfer rates were analyzed both cross-sectionally and longitudinally. The longitudinal analysis indicated that damage to white matter regions in the frontal lobe may be associated with AD progression. The study findings demonstrated that the magnetization transfer rate of frontal white matter may be a promising biomarker for AD.

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