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Abstract #0635

Cortical thickness is a sensitive biomarker for characterizing the gray matter abnormities in neonates with mild white matter injury

Miaomiao Wang1, Jing Xia2, Jian Chen2, Xianjun Li1, Congcong Liu1, Li Wang2, XiaoCheng Wei3, Gang Li2, Dinggang Shen2, and Jian Yang1

1Department of Diagnostic Radiology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China, 2Department of Radiology and BRIC, University of North Carolina at Chapel Hill, North Carolina, NC, United States, 3MR Research China, GE Healthcare, Beijing, China

White matter injury is common in neonates. The most common punctate white matter lesions (PWML) can disappear along with time and are easily missed diagnosis, but quantitative measurements may find more subtle alterations. Since DTI is not sensitive to detect the white-matter microstructural changes in mild PWML, alterations in gray-matter (GM) may provide additional knowledge for predicting prognosis. This study aims to quantitatively assess alterations of GM in neonates with mild PWML. Compared with controls, a significant reduction of cortical volume is observed in neonates with mild PWML, and cortical thickness is a sensitive biomarker for characterizing the GM abnormalities.

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