Understanding sources of R2* in the brains of infants and adults could lead to novel imaging biomarkers that could inform clinicians and researchers about white matter microstructure, and iron and myelin content. These biomarkers could in turn help determine the health, disease state, or developmental progress of white matter tissue, with many potential benefits to diagnosis, treatment, and therapeutic research. As opposed to adults who show a remarkable fit of R2* against fibre orientation, neonates showed very little dependence on myelin or fibre orientation.
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