Pancreatic stiffness was investigated using multifrequency MR elastography (MRE) and tomoelastography data processing in healthy controls (CTR) and patients with pancreatic ductal adenocarcinoma (PDAC). In healthy volunteers, tomoelastography was highly reproducible and showed no significant influences of region and age on pancreatic stiffness. Furthermore, we show that PDAC can be detected as stiff masses with full separation of MRE-values between CTR and PDAC. MRE-based tumor volume correlated excellently with CT-volumetry. Tomoelastography is well suited for boundary detection of pancreatic tumors within standardized, quantitative and contrast-agent free imaging examinations.