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Abstract #0648

X-ray microcomputed tomography as a natively isotropic, nondestructive, 3D validation dataset for diffusion MRI

Scott Trinkle1, Sean Foxley1, Narayanan Kasthuri2,3, and Patrick La Rivière1

1Department of Radiology, The University of Chicago, Chicago, IL, United States, 2Department of Neurobiology, The University of Chicago, Chicago, IL, United States, 3Argonne National Lab, Lemont, IL, United States

In this work, we present the use of synchotron x-ray microcomputed tomography (microCT) as a validation dataset for diffusion tensor imaging (DTI). DTI data were acquired of a post-mortem mouse brain. After metal staining, synchrotron microCT data of the sample were acquired, with 1.2 μm isotropic resolution across the whole brain. Orientation distribution functions were calculated from the microCT data using structure tensor analysis, and tractography was performed on the anterior commissure tract. Comparisons with tractography results from the diffusion MRI data show good agreement.

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