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Abstract #0651

Validating MR axon diameter mapping using confocal microscopy

Jelle Veraart1,2,3, Daniel Nunes1, Els Fieremans3, Dmitry S. Novikov3, and Noam Shemesh1

1Champalimaud Centre for the Unknown, Lisbon, Portugal, 2iMinds - Vision Lab, University of Antwerp, Antwerp, Belgium, 3Center for Biomedical Imaging, NYU School of Medicine, New York, NY, United States

Axon diameter mapping using diffusion MRI in the rat corpus callosum was validated using confocal microscopy with a staining for neurofilaments. When confounding factors such as extra-axonal water and dispersion are addressed, the effective MR axon radii are in good quantitative agreement with histology. However, using MRI, we are limited to the estimation of a single metric representing the entire distribution, which has shown to be dominantly sensitive to the largest axons in the voxel volume of interest.

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